DGAT: Key Player in Lipid Metabolism and Cellular Signaling (P16212)

Target Name: Diacylglycerol Acyltransferase (DGAT)

NCBI ID: P16212

Other Name(s): DGAT

DGAT: Key Player in Lipid Metabolism and Cellular Signaling

Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) (DGAT) is a protein that is expressed in various tissues throughout the body. It is a key player in the lipid metabolism, and is involved in the transfer of dietary fatty acids from the intestinal microbiota to the liver for energy storage.

DGAT is a transmembrane protein that is expressed in the liver, as well as other tissues such as the heart, muscle, and brain. It is a glycophospholipid-binding protein, which means that it interacts with lipids in the cell membrane. This protein is also known as DGATL, or N nonspecific subtype.

One of the key functions of DGAT is its role in lipid metabolism. It is involved in the transfer of dietary fatty acids from the intestinal microbiota to the liver for energy storage. DGAT is a key player in the process of lipid oxidation, which is the breakdown of dietary fat by the body's tissues to produce energy.

DGAT is also involved in the metabolism of cholesterol. It is a cholesterol acceptor, which means that it can accept cholesterol from the liver. This is important for maintaining the structure and function of cell membranes.

In addition to its role in lipid metabolism, DGAT is also involved in the regulation of cellular signaling pathways. It is a signaling molecule that can activate the JAK/STAT3 pathway, which is involved in the regulation of inflammation, immune response, and cellular signaling.

DGAT is also a potential drug target. Its involvement in lipid metabolism and cellular signaling pathways makes it a promising target for the development of new treatments for various diseases. For example, DGAT has been shown to be involved in the development of certain types of cancer , and may be a useful target for cancer therapies.

In conclusion, DGAT is a key player in the lipid metabolism and cellular signaling pathways. Its involvement in these processes makes it a promising target for the development of new treatments for various diseases. Further research is needed to fully understand the role of DGAT in lipid metabolism and cellular signaling pathways, and to develop effective therapies based on these insights.

Protein Name: Diacylglycerol Acyltransferase (DGAT) (nonspecified Subtype)

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